Combined low-FOXP3+ and -CD3+tumor infiltrating lymphocytes: a signature of stage II MSS colorectal cancer at high-risk of recurrence
نویسندگان
چکیده
Methods FoxP3+ and CD3+TIL densities were measured as the percentage of immune-reactive area (IRA%) at the tumor invasion front, in a consecutive series of 413 patients (pts) undergone radical surgery for pT3-pT4, stage II (n=211) and III (n=202) CRC, characterized for MS status. Recursive partitioning, as well logistic univariate, interaction, and multivariate analysis were employed for the integrated examination of pathological and immune markers in predicting recurrence.
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